Anti-inflammatory properties of the extract of maruna virgin (Tanacetum parthenium L.) on the model of chronic inflammation modeled by the Freund’ adjuvant in rats

Еhe aim of the study was to investigate effectiveness a thick extract feverfew (Tanacetum parthenium L.) herb in chronic inflammation (adjuvant arthritis) rats.
 The anti-inflammatory properties water-alcohol (ETP) were studied model adjuvant arthritis (ADA) (0.1 ml Freund's (PAF), once subcutaneously at base tail white nonlinear male rats (body weight 200–220 g). After 7 days, introduction PAF repeated (subcutaneously right hind paw rats). animals divided into 4 groups 9 each, intact group – 6 animals. Distilled water (1 ml/100 g) administered positive control (PCs) on background pathology. An aqueous solution ETP (50 mg/kg) and diclofenac sodium (1% starch suspension, 8 from day 1 experiment for four weeks daily intragastrically daily. volume affected foot (V) measured using LE7500 plethysmometer (PANLAB, Italy) dynamics 1, 5, 10, 15, 20, 25 30 days after administration permissive dose PAF. intensity assessed by peripheral blood parameters, biochemical indicators - markers inflammatory process. Statistical analysis data performed standard software package «Statistica v. 6.0». Differences between considered statistically significant p <0.05.
 course ADA characterized development systemic inflammation, as evidenced an increase number leukocytes, increased erythrocyte sedimentation rate (ESR) content C-reactive protein (CRP). A level LF sialic acids indicates membrane-destructive processes connective tissue. Against significantly decreased main indicator CRP 2 times, destruction joint tissue acid 1.9 times relative PC animals, indicating effect local manifestations ADA. not inferior (DS).
 Based obtained, it can be concluded that 50 mg/kg has pronounced is sodium, which makes promising further research effective agent.